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what is the most efficacious statin

1 Simvastatin is the most lipophilic statin. Rosuvastatin: a highly efficacious statin for the treatment of dyslipidaemia Expert Opin Investig Drugs . Curr Med Res Opin. Author Michael H Davidson 1 Affiliation 1 … The report, published recently by JAMA and simultaneously presented at the American College of Cardiology’s 65th Annual Scientific Session in Chicago, is the first major trial of its kind. Efforts to define the genetic architecture underlying variable statin response have met with limited success possibly because previous studies were limited to effect based on one-single-dose. 2020 Jul 2;21(13):4725. doi: 10.3390/ijms21134725. Strandberg TE, Feely J, Sigurdsson EL; DISCOVERY study group. Notes. Lin BM, Li WQ, Cho E, Curhan GC, Qureshi AA. 2017 Apr 22;15(2):e43319.  |  Effects of Different Types of Statins on Lipid Profile: A Perspective on Asians. NLM Clin Ther. Evidence-Based Treatment of Hypercholesterolemia: Patient-Centered Evaluation and Management, What do we Currently Know about the Cardiovascular Benefits of GLP-1 RAs? A Primer for Pharmacists (ARCHIVED), Uncovering Estrogen’s Role in CVD Protection in Premenopausal Women, Burdensome Preauthorization Process Limits Prescriptions for PCSK9 Inhibitors for Hypercholesterolemia, Guideline-Preferred Diuretic, Chlorthalidone, Causes More Serious Side Effects, Cardiovascular Considerations With Prescription Opioids for Chronic Pain. 2002 Jan;11(1):125-41. doi: 10.1517/13543784.11.1.125. Quizlet flashcards, activities and games help you improve your grades. Anothaisintawee T, Udomsubpayakul U, McEvoy M, Lerdsitthichai P, Attia J, Thakkinstian A. J Cancer. The majority of HMG-CoA reductase inhibitory activity in plasma is associated with the parent rosuvastatin compound. Statins can be used in combination with other lipid-lowering drugs depending upon the lipid-profile of the patient or if a … Effect of rosuvastatin compared with other statins on lipid levels and National Cholesterol Education Program goal attainment for low-density lipoprotein cholesterol in a usual care setting. Get the latest public health information from CDC: https://www.coronavirus.gov. Rosuvastatin: a highly efficacious statin for the treatment of dyslipidaemia Expert Opin Investig Drugs. 2005 Aug;21(8):1307-15. doi: 10.1185/030079905X56529. This site needs JavaScript to work properly. HHS Get the latest research from NIH: https://www.nih.gov/coronavirus. 2002 Mar;11(3):455. Which statin is the most potent rosuvastatin which School Western University; Course Title PHARM 4350a; Type. Allison B. Goldfine, M.D. These structural properties render this statin the most efficient in terms of dose able to reduce HMG-CoA reductase activity by 50% (Davidson, 2002). Bullano MF, Wertz DA, Yang GW, Kamat S, Borok GM, Gandhi S, McDonough KL, Willey VJ. Rosuvastatin, like atorvastatin, has a plasma half-life of about 20 h and is a potent inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase. Statins study guide by nammik includes 30 questions covering vocabulary, terms and more. Statins are drugs that can reduce levels of cholesterol in the blood. Reproduction in whole or in part without permission is prohibited. Statin Treatment-Induced Development of Type 2 Diabetes: From Clinical Evidence to Mechanistic Insights. The DISCOVERY PENTA study: a DIrect Statin COmparison of LDL-C Value--an Evaluation of Rosuvastatin therapY compared with atorvastatin. 2016 Jun 30;84(3):536-546. doi: 10.3390/scipharm84030536. Cleveland—A new study documents muscle-related symptoms in patients with a history of statin-intolerance and determines which drug is a more effective option to lower their cholesterol. USA.gov. Twelve-week, multicenter, randomized, open-label comparison of the effects of rosuvastatin 10 mg/d and atorvastatin 10 mg/d in high-risk adults: a DISCOVERY study. Learn about the types, their uses, and the risks of taking statins here. Myopathy is defined in various ways. Investigation of the Bioequivalence of Rosuvastatin 20 mg Tablets after a Single Oral Administration in Mediterranean Arabs Using a Validated LC-MS/MS Method. Copyright © 2000 - 2020 Jobson Medical Information LLC unless otherwise noted. Please enable it to take advantage of the complete set of features! J Am Acad Dermatol. Expert Rev Cardiovasc Ther. Interview with Dr. Allison Goldfine on statins, the associated risk of diabetes, and the FDA’s response. Int J Endocrinol Metab. Click here to return to Weekly News Update.  |  Thus rosuvastatin was the most efficacious of all the statins, followed by atorvastatin and simvastatin Table 1).15 The STELLAR study8 also revealed that the Adult Treatment Panel III LDL cholesterol goal was achieved by 82% to 89% of patients treated with rosuvastatin 10 to 40 mg compared with 69% to 85% of patients treated with atorvastatin 10 to 80 mg. 2004 Nov;26(11):1821-33. doi: 10.1016/j.clinthera.2004.11.015. Epub 2017 Dec 5. Galicia-Garcia U, Jebari S, Larrea-Sebal A, Uribe KB, Siddiqi H, Ostolaza H, Benito-Vicente A, Martín C. Int J Mol Sci.

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